Geoffrey A. Preidis

Geoffrey A. Preidis, M.D., Ph.D.

Associate Professor

Email

geoffrey.preidis@bcm.edu

Positions

Associate Professor: Department of Pediatrics
Division of Gastroenterology, Hepatology & Nutrition
91��Ƶ and Texas Children's Hospital
Houston, Texas, United States

Associate Director: Medical Scientist Training Program (M.D./Ph.D.)

Faculty: Development, Disease Models & Therapeutics Graduate Program

Faculty: Immunology & Microbiology Graduate Program

Faculty: Clinical Scientist Training Graduate Program

Addresses

Pediatric Gastroenterology, Hepatology & Nutrition Research Laboratory (Office): Texas Children's Hospital
Feigin Tower 860.24
Houston, TX, 77030
United States
Phone: (832) 822-3617
Fax: (832) 825-4893
geoffrey.preidis@bcm.edu

Texas Children's Hospital (Hospital): 6701 Fannin Street
Houston, TX, 77030
United States
Phone: (832) 822-3131
gapreidi@texaschildrens.org

Pediatric Gastroenterology, Hepatology & Nutrition Research Laboratory (Lab): Texas Children's Hospital
Feigin Tower 860.01
Houston, TX, 77030
United States
Phone: (832) 822-3617
Fax: (832) 825-4893
gp147834@bcm.edu

Education

Clinical Fellowship at 91��Ƶ & Texas Children's Hospital: 06/2018 - Houston, Texas, United States; Pediatric Gastroenterology, Hepatology & Nutrition

Residency at 91��Ƶ & Texas Children's Hospital: 06/2014 - Houston, Texas, United States; Pediatrics

Internship at 91��Ƶ & Texas Children's Hospital: 06/2013 - Houston, Texas, United States; Pediatrics

MD from Baylor College Of Medicine: 05/2012 - Houston, Texas, United States

PhD from 91��Ƶ: 02/2011 - Houston, Texas, United States; Translational Biology and Molecular Medicine

AB from Harvard University: 06/2003 - Cambridge, Massachusetts, United States; Physics, cum laude

Certifications

Medical License: Texas Medical Board

Board Certification - General Pediatrics: American Board of Pediatrics

Board Certification - Pediatric Gastroenterology: American Board of Pediatrics

Professional Interests

Neonatal Gastroenterology, Hepatology & Nutrition
Sex Differences in Nutritional Physiology
Gut Microbiome and Probiotics
Neurogastroenterology and Motility
Liver and Intestinal Physiology
Undernutrition
Bile Acids
Nuclear Hormone Receptors
Postnatal Growth Failure

Professional Statement

Our goal is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition influences intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. Our work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and socioeconomic factors, including preterm and underweight newborns in the neonatal intensive care unit, adolescents with anorexia nervosa, and children with severe acute malnutrition in the developing world.

Websites

Selected Publications

Parkman HP, Wilson LA, Hasler WL, Grover M, Chumpitazi BP, Burton-Murray H, Sarosiek I, Moshiree B, Preidis GA, Shulman RJ, Miriel LA, Shade D, Kuo B, McCallum RW, Abell TL, Pasricha PJ; NIDDK Gastroparesis Clinical Research Consortium.. " " Neurogastroenterol Motil. 2026 ; 38 : e70287.
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Shane AL, Gonzalez MD, Roy AM, Preidis GA, Woodworth MH.. " " Clin Infect Dis. 2026 ; in press.
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Shane AL, Gonzalez MD, Roy AM, Preidis GA, Woodworth MH.. " " Clin Infect Dis. 2025 ; 81 (5) : e250-e262.
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Shane AL, Gonzalez MD, Roy AM, Preidis GA, Woodworth MH.. " " Clin Infect Dis. 2025 ; 81 (5) : 867-868.
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Peterson JAM, Frias JA, Miller AN, Soni KG, Zhang Y, Xia Z, Day JW, Preidis GA, Cooper TA.. " " Proc Natl Acad Sci USA. 2025 ; 122 : e2522788122.
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Amin A, Osborne S, Preidis GA, Gowda SH.. " " Neoreviews. 2025 ; 26 : e560-e563.
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Wan X, Soni KG, Choi JM, Jung SY, Conner ME, Preidis GA.. " " Am J Physiol Gastrointest Liver Physiol. 2025 ; 329 : G232-G243.
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Lynch LE, Lahowetz R, Maresso C, Terwilliger A, Pizzini J, Melendez Hebib V, Britton RA, Maresso AW, Preidis GA.. " " J Clin Invest. 2025 ; 135 : e184323.
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Pammi M, Preidis GA.. " " Pediatr Res. 2025 ; 98 (1) : 22-24.
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Tessier MEM, Shneider BL, Petrosino JF, Preidis GA.. " " J Pediatr Gastroenterol Nutr. 2025 ; in press
Preidis GA.. " " Gut Microbes. 2025 ; 17 : 2457499.
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Preidis GA, Berrington JE.. " " Nat Rev Gastroenterol Hepatol. 2025 ; 22 : 5-6.
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Britton RA, Verdu EF, Di Rienzi SC, Reyes Munoz A, Tarr PI, Preidis GA.. " " Gastroenterology. 2024 ; 167 : 1059-1064.
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Dike PN, Soni KG, Chang DS, Preidis GA.. " " FASEB Bioadv. 2024 ; 6 : 200-206.
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Chang DS, Soni KG, Preidis GA.. " " Front Neurol. 2024 ; 15 : 334319.
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Patel H, Harris RA, Qian JH, Oezguen N, Watson A, Szigeti RG, Cho S, Ruan W, Britto S, Opekun A, Preidis G, Kellermayer R.. " " Cell Mol Gastroenterol Hepatol. 2024 ; 17 : 1069-1071.
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Adeniyi-Ipadeola GO, Hoffman KL, Yang H, Javornik Cregeen SJ, Preidis GA, Ramani S, Hair AB.. " " Pediatr Res. 2024 ; 95 : 1564-1571.
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McFarland LV, Hecht G, Sanders ME, Goff DA, Goldstein EJC, Hill C, Johnson S, Kashi MR, Kullar R, Marco ML, Merenstein DJ, Millette M, Preidis GA, Quigley EMM, Reid G, Salminen S, Sniffen JC, Sokol H, Szajewska H, Tancredi DJ, Woolard K.. " " JAMA Netw Open. 2023 ; 6 : e2346872.
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Edwards PT, Soni KG, Conner ME, Fowler SW, Foong JPP, Stavely R, Cheng LS, Preidis GA.. " " Neurogastroenterol Motil. 2023 ; 35 : e14676.
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Preidis GA.. " " Manson's Tropical Diseases, 24th Edition. Farrar J, Garcia PJ, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, Eds. 2023 ; 1161-1177.
Shane AL, Preidis GA.. " " JAMA Pediatr. 2023 ; 177 (9) : 879-880.
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Neves LL, Hair AB, Preidis GA.. " " Gut Microbes. 2023 ; 15 : 2190301.
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Lynch LE, Hair AB, Soni KG, Yang H, Gollins LA, Narvaez-Rivas M, Setchell KDR, Preidis GA.. " " Gut Microbes. 2023 ; 15 : 2183690.
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Merenstein D, Pot B, Leyer G, Ouwehand AC, Preidis GA, Elkins CA, Hill C, Lewis ZT, Shane AL, Zmora N, Petrova MI, Collado MC, Morelli L, Montoya GA, Szajewska H, Tancredi DJ, Sanders ME.. " " Gut Microbes. 2023 ; 15 : 2185034.
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Holzapfel LF, Hair AB, Preidis GA, Halder T, Yang H, Unger JP, Freedman S, Martin, CR.. " " J Pediatr Gastroenterol Nutr. 2023 ; 76 : 206-212.
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Preidis GA, Chumpitazi BP, Shulman RJ.. " " In: Pediatric Neurogastroenterology. 2022 ; Springer Nature Switzerland AG (Faure C, Thapar N, Di Lorenzo C, Eds.) : 80-100.
Preidis GA.. " " J Pediatr Gastroenterol Nutr. 2022 ; 75 (4) : 387-388.
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Suh JH, Kim KH, Conner ME, Moore DD, Preidis GA.. " " Front Nutr. 2022 ; 9 : 831879.
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Patterson GT, Osorio EY, Peniche A, Dann SM, Cordova E, Preidis GA, Suh JH, Ito I, Saldarriaga OA, Loeffelholz M, Ajami NJ, Travi BL, Melby PC.. " " Front Immunol. 2022 ; 13 : 846155.
Amato KR, Arrieta MC, Azad MB, Bailey MT, Broussard JL, Bruggeling CE, Claud EC, Costello EK, Davenport ER, Dutilh BE, Ewald HAS, Ewald P, Hanlon EC, Keshavarzian A, Maurice CF, Miller G, Preidis GA, Segurel L, Singer B, Subramanian S, Julion W, et al.. " " Proc Natl Acad Sci USA. 2021 ; 118 : e2017947118.
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Preidis GA, Su GL, Morgan RL.. " " Gastroenterology. 2021 ; 160 : 2633-5.
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Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, Moore DD.. " " Hepatol Commun. 2020 ; 4 (12) : 1835-1850.
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Soni KG, Dike PN, Suh JH, Halder T, Edwards PT, Foong JPP, Conner ME, Preidis GA.. " " Neurogastroenterol Motil. 2020 ; 32 (12) : e13936.
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Edwards PT, Kashyap PC, Preidis GA.. " " Am J Physiol Gastrointest Liver Physiol. 2020 ; 319 : G382-390.
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Pammi M, Preidis GA, Tarnow-Mordi WO.. " " Biochem Cell Biol. 2021 ; 99 : 20-24.
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Morgan RL, Preidis GA, Kashyap PC, Weizman AV, Sadeghirad B.. " " Gastroenterology. 2020 ; 159 : 467-480.
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Preidis GA, Weizman AV, Kashyap PC, Morgan RL.. " " Gastroenterology. 2020 ; 159 : 708-738.
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Su GL, Ko CW, Bercik P, Morgan RL, Weizman AV, Kashyap P, Preidis GA.. " " Gastroenterology. 2020 ; 159 : 707.
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Soni KG, Halder T, Conner ME, Preidis GA.. " " Neurogastroenterol Motil. 2019 ; 31 : e13654.
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Ford SL, Lohmann P, Preidis GA, Gordon PS, O'Donnell A, Hagan J, Venkatachalam A, Balderas M, Luna RA, Hair AB.. " " Am J Clin Nutr. 2019 ; 109 : 1088-1097.
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Shin A, Preidis GA, Shulman R, Kashyap PC.. " " Clin Gastroenterol Hepatol. 2019 ; 17 : 256-274.
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Thaxton GE, Melby PC, Manary MJ, Preidis GA.. " " Gastroenterol Clin North Am. 2018 ; 47 : 813-827.
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Alves da Silva AV, de Castro Oliveira SB, Di Rienzi SC, Brown-Steinke K, Dehan LM, Rood JK, Carreira VS, Le H, Maier EA, Betz KJ, Aihara E, Ley RE, Preidis GA, Shen L, Moore SR.. " " Curr Dev Nutr. 2018 ; 3 : nzy070.
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Preidis GA, Kim KH, Moore DD.. " " J Clin Invest. 2017 ; 127 : 1193-1201.
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Velly H, Britton RA, Preidis GA.. " " Gut Microbes. 2017 ; 8 : 98-112.
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Preidis GA, Chumpitazi BP, Shulman RJ.. " " In: Pediatric Neurogastroenterology. 2017 ; Springer International Publishing, Switzerland (Faure C, Thapar N, Di Lorenzo C, Eds.) : 53-70.
Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF.. " " J Nutr. 2016 ; 146 : 940-8.
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Preidis GA, Chiou EH.. " " In: The NASPGHAN Fellows’ Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition - Second Edition. 2017 ; NASPGHAN, Ambler, PA (Li BUK, Hurtado CW, Eds.) : 655-59.
Preidis GA, Leung DH.. " " In: The NASPGHAN Fellows’ Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition - Second Edition. 2017 ; NASPGHAN, Ambler, PA (Li BUK, Hurtado CW, Eds.) : 353-57.
Preidis GA, Luna RA, Hollister EB, Schady D, Finegold MJ, Versalovic J, Shulman RJ.. " " Therap Adv Gastroenterol. 2016 ; 9 (5) : 749-51.
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Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF.. " " J Nutr Biochem. 2015 ; 26 : 1050-7.
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Preidis GA, Hotez PJ.. " " PLoS Negl Trop Dis. 2015 ; 9 : e0003382.
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Ahmed S, Kim MH, Dave AC, Sabelli R, Kanjelo K, Preidis GA, Giordano TP, Chiao E, Hosseinipour M, Kazembe PN, Chimbwandira F, Abrams EJ.. " " J Int AIDS Soc. 2015 ; 18 : 19305.
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LaCourse SM, Chester FM, Preidis G, McCrary LM, Maliwichi M, McCollum ED, Hosseinipour MC.. " " J Trop Pediatr. 2015 ; 61 : 44-53.
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LaCourse SM, Chester FM, Preidis G, McCrary LM, Arscott-Mills T, Maliwichi M, James G, McCollum ED, Hosseinipour MC.. " " Pediatr Infect Dis J. 2014 ; 33 : 1200-2.
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Finocchario-Kessler S, Gautney B, Khamadi S, Okoth V, Goggin K, Spinler J, Mwangi A, Kimanga D, Clark K, Olungae H, Preidis GA.. " " AIDS. 2014 ; 28 : S313-21.
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Perry SH, Swamy P, Preidis GA, Mwanyumba A, Motsa N, Sarero HN.. " " AIDS. 2014 ; 28 : 791-3.
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Preidis GA, Keaton MA, Campeau P, Bessard BC, Conner ME, Hotez PG.. " " J Nutr. 2014 ; 144 : 273-81.
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McCollum ED, Preidis GA, Maliwichi M, Olson D, McCrary M, Kazembe PN, van der Horst C, Hoffman I, Hosseinipour MC.. " " J Acquir Immun Defic Syndr. 2014 ; 66 : 223-30.
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Bjornstad, E, Preidis GA, Lufesi N, Olson D, Kamthunzi P, Hosseinipour M, McCollum ED.. " " Paediatr Int Child Health. 2014 ; 34 : 29-36.
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Olson D, Preidis GA, Milazi R, Spinler JK, Lufesi N, Mwansambo C, Hosseinipour MC, McCollum ED.. " " Trop Med Int Health. 2013 ; 18 : 879-86.
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Kim MH, Ahmed S, Preidis GA, Abrams EJ, Hosseinipour MC, Giordano TP, Chiao EY, Paul ME, Bhalakia A, Nanthuru D, Kazembe PN.. " " PLoS One. 2013 ; 8 : e64979.
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Olson D, Davis NL, Milazi R, Miller W, Mwansambo C, Preidis GA, Hosseinipour MC, McCollum ED.. " " Trop Med Int Health. 2013 ; 18 : 871-8.
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McCollum ED, Bjornstad E, Preidis GA, Hosseinipour MC, Lufesi N.. " " Trans R Soc Trop Med Hyg. 2013 ; 107 : 285-92.
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Preidis GA, McCollum ED, Garbino A, Kamiyango W, Hosseinipour MC, Kazembe PN, Schutze GE, Kline MW.. " " J Acquir Immune Defic Syndr. 2013 ; 63 : e16-22.
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Kim MH, Ahmed S, Buck WC, Preidis GA, Hosseinipour MC, Bhalakia A, Nanthuru D, Kazembe PN, Chimbwandira F, Giordano TP, Chiao EY, Schutze GE, Kline MW.. " " J Int AIDS Soc. 2012 ; 15 : 1-11.
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Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Barrish JP, Finegold MJ, Petrosino JF, Guerrant RL, Conner ME, Versalovic J.. " " J Pediatr Gastroenterol Nutr. 2012 ; 55 : 299-307.
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Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Finegold MJ, Petrosino JF, Conner ME, Versalovic J.. " " FASEB J. 2012 ; 26 : 1960-9.
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Preidis GA, McCollum ED, Mwansambo C, Kazembe PN, Schutze GE, Kline MW.. " " J Pediatr. 2011 ; 159 : 484-9.
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McCollum ED, Preidis GA, Golitko C, Siwande LD, Mwansambo C, Kazembe PN, Hosseinipour MC, Schutze GE, Kline MW.. " " Pediatr Infect Dis J. 2011 ; 30 : e75-81.
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Thomas CM, Preidis GA, Versalovic J.. " " Old Herborn University Seminars. 2011 ; 24 : 83-94.
Preidis GA, Hill C, Guerrant RL, Ramakrishna BS, Tannock GW, Versalovic J.. " " Gastroenterology. 2011 ; 140 : 8-14.
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Preidis GA, Shapiro CD, Pierre I, Dyer MJ, Kozinetz CA, Grimes RM.. " " J Health Care Poor Underserved. 2010 ; 21 : 430-7.
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McCollum ED, Preidis GA, Kabue MM, Singogo EBM, Mwansambo C, Kazembe PN, Kline MW.. " " PLoS One. 2010 ; 5 : e9626.
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Preidis GA, Versalovic J.. " " Gastroenterology. 2009 ; 136 : 2015-31.
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Preidis GA, Huang HC, Lewis DE, Castellanos-Gonzalez A, Rogers KA, Ward HD, White AC.. " " Am J Trop Med Hyg. 2007 ; 77 : 583-5.
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Popovich PG, van Rooijen N, Hickey WF, Preidis G, McGaughy V.. " " Exp Neurol. 2003 ; 182 : 275-87.
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Funding

Advancing Clinical Science in Pediatric Gastroparesis #U01 DK112194: (09/25/2016 - 07/31/2027); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases

The Metabolic Basis for Impaired Bile Acid Synthesis in Malnutrition #R01 DK133301: (07/15/2022 - 06/30/2027); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases

Impaired Bile Acid Synthesis Due To CYP7A1 and CYP7B1 Suppression in Malnutrition #R03 DK129495-01: (07/15/2021 - 06/30/2023); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases

Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy Undernutrition #K08 DK113114-01: (09/01/2017 - 08/31/2022); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases; K08 Mentored Clinical Scientist Research Career Development Award

Bile Acid and Metagenomic Profiles in Very Low Birthweight Preterm Neonates: (05/06/2020 - 05/05/2022); Grant funding from Men of Distinction

AGA-Rome Foundation Functional GI and Motility Disorders Pilot Award: (07/01/2017 - 06/30/2018); Grant funding from American Gastroenterological Association / Rome Foundation; Bile Acid Mediated Dysmotility in Protein-Energy Undernutrition

Chao Physician-Scientist Award: (07/01/2017 - 08/31/2017); Grant funding from Ting Tsung and Wei Fong Chao Foundation; Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy Undernutrition

ANMS Research Grant: (01/01/2017 - 06/30/2017); Grant funding from American Neurogastroenterology and Motility Society; Bile Acids and Intestinal Dysmotility in Early-Life Undernutrition

Functional and Mechanistic Award: (11/01/2016 - 06/30/2017); Grant funding from The Alkek Center for Metagenomics and Microbiome Research; Microbial Mechanisms of Pathogenesis Underlying non-Helicobacter Gastritis

Pilot/Feasibility Award: (02/06/2016 - 02/05/2018); Grant funding from The Texas Medical Center Digestive Disease Center; Persistent Epigenetic and Metabolic Consequences of Early Undernutrition.

NASPGHAN Foundation / Nestle Nutrition Research Young Investigator Development Award: (11/15/2015 - 11/14/2017); Grant funding from North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition; Glycan metabolism shapes the undernourished intestinal microbiome and influences weight gain

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) #5T32DK007664: (07/01/2015 - 08/31/2017); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases; Mechanisms of Dysregulation of Bile Acid Synthesis in Protein-Energy Undernutrition

Early Career Award: (10/01/2013 - 09/30/2014); Grant funding from Thrasher Research Fund; The Intestinal Microbiome as a Biomarker and Therapeutic Target in Severe Acute Malnutrition

Young Investigator Grant for Probiotics Research: (07/01/2013 - 06/30/2014); Grant funding from Global Probiotics Council; Elucidating the Role of the Intestinal Microbiome in Protein-Energy Undernutrition

Ruth L. Kirschstein National Research Service Award for Individual Predoctoral M.D./Ph.D. Fellows (F30) #5F30DK081269: (06/01/2009 - 05/30/2012); Grant funding from National Institute of Diabetes and Digestive and Kidney Diseases; Mechanisms of Immunomodulation by Probiotic L. reuteri in Acute Gastroenteritis

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