Harold David Shine

Harold David Shine, Ph.D.

Professor Emeritus

(713) 898-6560

Email

hshine@bcm.edu

Positions

Professor Emeritus: Department of Neuroscience
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Houston, TX, US

Education

Post-Doctoral Fellowship at Harvard Medical School: 01/1983 - Boston, Massachusetts, United States

PhD from University Of Texas Medical School At Galveston: 01/1980 - Galveston, Texas, United States

MA from University Of Texas At Austin: 01/1975 - Austin, Texas, United States

BA from University Of Texas At Austin: 01/1973 - Austin, Texas, United States

BA from Texas Tech University: 09/1972 - Lubbock, Texas, United States

Professional Interests

Gene therapy of the nervous system
Spinal Cord Injury
Neuroimmunology of neural trauma

Professional Statement

The research interests of our laboratory focus on the molecular and cellular bases of disease and trauma of the nervous system with a translational emphasis. Our primary research emphasis is the study of the role of neurotrophic factors in CNS degeneration and regeneration as a consequence of trauma or neurodegenerative disease and their possible therapeutic use. Using viral vectors carrying genes for neurotrophic factors we have shown in animal models of CNS injury we can spare neurons from axotomy-induced neuronal death and support axonal sprouting after neural injury. Recently, we learned that neuroinflammation is required for regenerative effects of the neurotrophic factors and are now studying this phenomenon to determine its mechanism.

Techniques used in the laboratory span from gene cloning, through small animal neurosurgery, light and confocal microscopy, neuroimmunology, to animal behavior.

Websites

Selected Publications

Chen, Q and Shine, HD. " Neuroimmune processes associated with Wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord.. " J Neurosci Res. 2013 ; 91 : 1280-1291.
Chen Q, Smith GM, Shine HD. " " Exp. Neurol.. 2008 Feb ; 209 (2) : 497-509.
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Chen Q, Zhou L, Shine HD. " " J. Neurotrauma. 2006 Aug ; 23 (8) : 1254-60.
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Zhou L, Shine HD. " " J. Neurosci. Res.. 2003 Oct 15; 74 (2) : 221-6.
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Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD. " " Science. 2002 Aug 23; 297 (5585) : 1299.
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Popko B, Puckett C, Lai E, Shine HD, Readhead C, Takahashi N, Hunt SW, Sidman RL, Hood L. " " Cell. 1987 Feb 27; 48 (4) : 713-21.
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Readhead C, Popko B, Takahashi N, Shine HD, Saavedra RA, Sidman RL, Hood L. " " Cell. 1987 Feb 27; 48 (4) : 703-12.
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Shine HD, Hertz L, De Vellis J, Haber B. " " Neurochem. Res.. 1981 Apr ; 6 (4) : 453-63.
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Shine HD, Perez-Polo JR. " " J. Neurochem.. 1976 Mar ; 26 (3) : 513-9.
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Goodman JC, Trask TW, Chen SH, Woo SL, Grossman RG, Carey KD, Hubbard GB, Carrier DA, Rajagopalan S, Aguilar-Cordova E, Shine HD. " " Hum. Gene Ther.. 1996 Jun 20; 7 (10) : 1241-50.
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Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD. " " Brain Res.. 1995 Sep 11; 691 (41276) : 76-82.
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Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HD. " " Hum. Gene Ther.. 1995 Oct ; 6 (10) : 1317-22.
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Perez-Cruet MJ, Trask TW, Chen SH, Goodman JC, Woo SL, Grossman RG, Shine HD. " " J. Neurosci. Res.. 1994 Nov 1; 39 (4) : 506-11.
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Kirkpatrick LL, Witt AS, Payne HR, Shine HD, Brady ST. " " J. Neurosci.. 2001 Apr 1; 21 (7) : 2288-97.
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Macklis JD, Sidman RL, Shine HD. " " In Vitro Cell. Dev. Biol.. 1985 Mar ; 21 (3) : 189-94.
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Shine HD, Harcourt PG, Sidman RL. " " J. Neurosci. Res.. 1985 ; 14 (4) : 393-401.
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Jensen NA, Smith GM, Garvey JS, Shine HD, Hood L. " " J. Neurosci. Res.. 1993 Jun 15; 35 (3) : 288-96.
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Baumgartner BJ, Shine HD. " " J. Neurosci. Res.. 1998 Dec 15; 54 (6) : 766-77.
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Jensen NA, Smith GM, Shine HD, Garvey JS, Hood L. " " J. Neurosci. Res.. 1993 Feb 15; 34 (3) : 257-64.
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Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. " " Breast Cancer Res. Treat.. 2002 May ; 73 (1) : 75-83.
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Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SL. " " Proc. Natl. Acad. Sci. U.S.A.. 1994 Apr 12; 91 (8) : 3054-7.
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Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. " " Exp. Eye Res.. 2008 Dec ; 87 (6) : 580-6.
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Shine HD, Haber B. " " Brain Res.. 1981 Aug 3; 217 (2) : 339-49.
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Smith GM, Shine HD. " " Int. J. Dev. Neurosci.. 1992 Oct ; 10 (5) : 387-92.
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Shine HD, Sidman RL. " " J. Cell Biol.. 1984 Apr ; 98 (4) : 1291-5.
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Zou L, Yuan X, Long Y, Shine HD, Yang K. " " Hum. Gene Ther.. 2002 Dec 10; 13 (18) : 2173-84.
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Grider MH, Mamounas LA, Le W, Shine HD. " " J. Neurosci. Res.. 2005 Nov 1; 82 (3) : 404-12.
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Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D. " " Prostate. 2001 Nov 1; 49 (3) : 213-23.
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Grider MH, Park D, Spencer DM, Shine HD. " " J. Neurosci. Res.. 2009 Nov 1; 87 (14) : 3033-42.
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Shine HD, Readhead C, Popko B, Hood L, Sidman RL. " " J. Neurochem.. 1992 Jan ; 58 (1) : 342-9.
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Shine HD, Readhead C, Popko B, Hood L, Sidman RL. " " Prog. Clin. Biol. Res.. 1990 ; 336 : 81-92.
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Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. " " Exp. Eye Res.. 2008 Jan ; 86 (1) : 34-40.
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Baumgartner BJ, Shine HD. " " Exp. Neurol.. 1998 Sep ; 153 (1) : 102-12.
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Shine HD, Wyde PR, Aguilar-Cordova E, Chen SH, Woo SL, Grossman RG, Goodman JC. " " Gene Ther.. 1997 Apr ; 4 (4) : 275-9.
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Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR, Shine HD. " " J. Neurosci.. 2003 Feb 15; 23 (4) : 1424-31.
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Sánchez I, Hassinger L, Paskevich PA, Shine HD, Nixon RA. " " J. Neurosci.. 1996 Aug 15; 16 (16) : 5095-105.
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Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. " " Mol. Vis.. 2007 ; 13 : 1934-41.
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Rabinovsky ED, Smith GM, Browder DP, Shine HD, McManaman JL. " " J. Neurosci. Res.. 1992 Jan ; 31 (1) : 188-92.
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Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen SH, Woo SL, Grossman RG. " " Mol. Ther.. 2000 Feb ; 1 (2) : 195-203.
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Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR. " " Proc. Natl. Acad. Sci. U.S.A.. 2003 Dec 23; 100 (26) : 15877-82.
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Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk S. " " Cancer Res.. 2007 Jun 15; 67 (12) : 5957-64.
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Readhead C, Takasashi N, Shine HD, Saavedra R, Sidman R, Hood L. " " Ann. N. Y. Acad. Sci.. 1990 ; 605 : 280-5.
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Grider MH, Chen Q, Shine HD. " " J. Neurosci. Methods. 2006 Sep 15; 155 (2) : 172-9.
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Baumgartner BJ, Shine HD. " " J. Neurosci.. 1997 Sep 1; 17 (17) : 6504-11.
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Smith GM, Rabinovsky ED, McManaman JL, Shine HD. " " Exp. Neurol.. 1993 Jun ; 121 (2) : 239-47.
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Shine HD, Perez-Polo JR. " " J. Neurochem.. 1976 Dec ; 27 (6) : 1315-8.
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Funding

Identification of T cell subtypes necessary for NT-3 induced neuroplasticity using a novel human-to-rat graft strategy: Mission Connect

Inflammation-associated factors that support neuroplasticity in chronic spinal cord injury: Christopher and Dana Reeve Foundation

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