91¹ú²úÊÓƵ

Email

ismael.alramahi@bcm.edu

Positions

Assistant Professor

Molecular and Human Genetics
Jan and Dan Duncan Neurological Research Institute
91¹ú²úÊÓƵ
Houston, TX, US

Addresses

Jan and Dan Duncan Neurological Research Institute (Office)

1250 Moursund St.
Room: Suite-N1025.20
Houston, TX, 77030
United States
Phone: (832) 824-8122

Education

BS from Univerisdad Autonoma

06/2001 - Madrid, Spain

PhD from Universidad Autonoma

11/2007 - Madrid, Spain

Postdoctoral Fellowship at 91¹ú²úÊÓƵ

Houston, United States

Websites

Selected Publications

• George A Edwards 3rd, Caleb A Wood, Yang He, Quynh Nguyen, Peter J Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L Jankowsky. " " Acta Neuropathol.. 2024 Mar 25; 147 (61)
  Pubmed PMID: .
• T. Bourquard, K. Lee, Ismael Al-Ramahi (Co-First), M. Pham, D. Shapiro, Y. Lagisetty, S. Soleimani, S. Mota, K. Wilhelm, M. Samieinasab, Y. W. Kim, E. Huh, J. Asmussen, P. Katsonis, J. Botas, O. Lichtarge. " " Nat Commun.. 2023 May 13; 14 (2765)
  Pubmed PMID: .
• Al-Ramahi I, Lu B, Di Paola S, Pang K, de Haro M, Peluso I, Gallego-Flores T, Malik NT, Erikson K, Bleiberg BA, Avalos M, Fan G, Rivers LE, Laitman AM, Diaz-García JR, Hild M, Palacino J, Liu Z, Medina DL, Botas J.. " " Cell Syst.. 2018 Jul ;
  Pubmed PMID: .
• Young Won Kim, Ismael Al-Ramahi (Co-First), Amanda Koire, Stephen J Wilson, Daniel M Konecki, Samantha Mota, Shirin Soleimani, Juan Botas, Olivier Lichtarge. " " Alzheimers Dement.. 2020 Dec 7; 17 (5)
  Pubmed PMID: .
• Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.. " " Elife. 2017 Dec ;
  Pubmed PMID: .
• select Stephens MC, Li J, Mair M, Moore J, Zhu K, Tarkunde A, Amoh B, Perez AM, Bhakare A, Guo F, Shulman JM, Al-Ramahi I, Botas J. " " Am J Hum Genet. 2025 May 1; 112 (5) : 1081-1096.
  Pubmed PMID: .
• Spargo TP, Sands CF, Juan IR,..., Hollis B, Cuddapah VA, Zoghbi HY, Shulman JM, Petrovski S, Al-Ramahi I, Tachmazidou I, Dhindsa RS. " " Cell Rep. 2025 Mar 25; 44 (3)
  Pubmed PMID: .
• Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J. " " NPJ Parkinsons Dis. 2025 Mar 11; 11 (46)
  Pubmed PMID: .
• Wu T, Deger JM, Ye H, Guo C, Dhindsa J, Pekarek BT, Al-Ouran R, Liu Z, Al-Ramahi Ismael, Botas J, Shulman JM.. " " Elife. 2023 May 23; 12
  Pubmed PMID: .
• Yu M, Ye H, De-Paula RB, Mangleburg CG, Wu T, Lee TV, Li Y, Duong D, Phillips B, Cruchaga C, Allen GI, Seyfried NT, Al-Ramahi Ismael, Botas J, Shulman JM.. " " PLoS Genet.. 2023 May 18; 19 (5)
  Pubmed PMID: .
• R. Benyair, S. S. P. Giridharan, P. Rivero-Ríos, J. Hasegawa, E. Bristow, Eeva-Liisa Eskelinen, M. D. Shmueli, V. Fishbain-Yoskovitz, Y. Merbl, L. M. Sharkey, H. L. Paulson, P. I. Hanson, S. Patnaik, Ismael Al-Ramahi, J. Botas, J. Marugan, L. S. Weisman. " " Autophagy Rep.. 2023 Apr 13; 2(1) (2166722)
  Pubmed PMID: .
• Jiyoen Kim, Maria de Haro, Ismael Al-Ramahi, Lorena Laura Garaicoechea, Hyun-Hwan Jeong, Jun Young Sonn, Bakhos Tadros, Zhandong Liu, Juan Botas, Huda Yahya Zoghbi. " " Neuron. 2023 Mar 15; 111 (6) : 824-838.
  Pubmed PMID: .
• Y. Lagisetty, T. Bourquard, Ismael Al-Ramahi, C. G.Mangleburg, S. Mota, S. Soleimani, J. M. Shulman, J. Botas, K. Lee, O. Lichtarge. " " Cell Genom.. 2022 Sep 14; 2(9) (100162)
  Pubmed PMID: .
• J. Li, B. K. Amoh, E. McCormick, A. Tarkunde, K. F. Zhu, A. Perez, M. Mair, J. Moore, J. M Shulman, Ismael Al-Ramahi, J. Botas. " " Hum Mol Genet .. 2023 Jan 27; 32 (4) : 685–695.
  Pubmed PMID: .
• Won-Seok Lee, Ismael Al-Ramahi, Hyun-Hwan Jeong, Youjin Jang, Tao Lin, Carolyn J. Adamski, Laura A. Lavery, Smruti Rath, Ronald Richman, Vitaliy V. Bondar, Elizabeth Alcala, Jean-Pierre Revelli, Harry T. Orr, Zhandong Liu, Juan Botas, and Huda Y. Zoghbi. " " J Clin Invest .. 2022 May 2; 132 (9)
  Pubmed PMID: .
• Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea. " " Cell Syst.. 2022 Apr 20; 13 (4) : 304-320.
  Pubmed PMID: .
• Xiaodan Zhang, Xue Wen, Ismael Al-Ramahi, Juan Botas, Boxun Lu, Yuhua Fu. " " Neurosci Bull.. 2022 Jan ; 38 (1) : 99-103.
  Pubmed PMID: .
• Onur TS, Laitman A, Zhao H, Keyho R, Kim H, Wang J, Mair M, Wang H, Li L, Perez A, de Haro M, Wan YW, Allen G, Lu B, Al-Ramahi I, Liu Z, Botas J.. " " Elife.. 2021 Apr 19;
  Pubmed PMID: .
• Suart CE, Perez AM, Al-Ramahi I, Maiuri T, Botas J, Truant R.. " " Hum Mol Genet.. 2021 May 17; 30 (8) : 706-715.
  Pubmed PMID: .
• Lee WS, Lavery L, Rousseaux MWC, Rutledge EB, Jang Y, Wan YW, Wu SR, Kim W, Al-Ramahi I, Rath S, Adamski CJ, Bondar VV, Tewari A, Soleimani S, Mota S, Yalamanchili HK, Orr HT, Liu Z, Botas J, Zoghbi HY.. " " EMBO J .. 2021 Apr 1; 40 (7)
  Pubmed PMID: .
• Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JL.. " " Hum Mol Genet .. 2019 Jun 15; 28 (12) : 2014-2029.
  Pubmed PMID: .
• Maxime W.C. Rousseaux, Gabriel E. Vázquez-Vélez, Ismael Al-Ramahi, Hyun-Hwan Jeong, Aleksandar Bajic, Jean-Pierre Revelli, Hui Ye, Emily T. Phan, Jennifer M. Deger, Alma M. Perez, Ji-Yoen Kim, Laura A. Lavery, Qikia Xu, Mamie Z. Li, et. al.. " " Journal of Neuroscience. 2018 Sep ;
• Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY.. " " Neuron. 2016 Oct ;
  Pubmed PMID: .
• Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY.. " " Elife. 2016 Oct ;
  Pubmed PMID: .
• Soriano S, Calap-Quintana P, Llorens JV, Al-Ramahi I, Gutiérrez L, Martínez-Sebastián MJ, Botas J, Moltó MD.. " " PLoS One.. 2016 Jul ;
  Pubmed PMID: .
• Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW.. " " Nat Neurosci.. 2016 Apr ;
  Pubmed PMID: .
• El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F.. " " Embo J. 2015 Jul ;
  Pubmed PMID: .
• Calap-Quintana P, Soriano S, Llorens JV, Al-Ramahi I, Botas J, Moltó MD, Martínez-Sebastián MJ.. " " PLoS One.. 2015 Jul ;
  Pubmed PMID: .
• Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B.. " " Elife.. 2015 Mar ;
  Pubmed PMID: .
• Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW.. " " Sci Transl Med.. 2014 Dec ;
  Pubmed PMID: .
• Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JS, Orr HT, Westbrook TF, Botas J, Zoghbi HY.. " " Nature.. 2013 Jun ;
  Pubmed PMID: .
• de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas J.. " " PLoS Genet.. 2013 Apr ;
  Pubmed PMID: .
• Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J.. " " Nat Neurosci.. 2013 May ;
  Pubmed PMID: .
• Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE.. " " PLoS Genet.. 2012 Nov ;
  Pubmed PMID: .
• Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW.. " " Neuron.. 2012 Jul ;
  Pubmed PMID: .
• Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM.. " " J Biol Chem.. 2012 Jun ;
  Pubmed PMID: .
• Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM.. " " Neuron.. 2010 Jul ;
  Pubmed PMID: .
• de Haro M, Al-Ramahi I, Benito-Sipos J, López-Arias B, Dorado B, Veenstra JA, Herrero P.. " " Cell Tissue Res.. 2010 Feb ;
  Pubmed PMID: .
• Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J.. " " PLoS Genet.. 2007 Dec ;
  Pubmed PMID: .
• Branco J, Al-Ramahi I, Ukani L, Pérez AM, Fernandez-Funez P, Rincón-Limas D, Botas J.. " " Hum Mol Genet.. 2008 Feb ;
  Pubmed PMID: .
• Al-Ramahi I, Lam YC, Chen HK, de Gouyon B, Zhang M, Pérez AM, Branco J, de Haro M, Patterson C, Zoghbi HY, Botas J.. " " J Biol Chem.. 2006 Sep ;
  Pubmed PMID: .
• de Haro M, Al-Ramahi I, De Gouyon B, Ukani L, Rosa A, Faustino NA, Ashizawa T, Cooper TA, Botas J.. " " Hum Mol Genet.. 2006 Jul ;
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Show 38 more publications

Funding

Decoding the impact of sex differences on Alzheimer's disease risk
#R01AG074009

$6,009,110.00   (06/30/2021 - 07/01/2026)

Grant funding from NIH-NIA

Alzheimer's disease affects approximately twice as many females compared to males. The reasons for this difference are largely unexplored. We combine computational approaches applied to whole exome/genome sequencing of patients and controls with in vivo (Drosophila, cells, mice) approaches to identify genes that carry differential risk of causing Alzheimer's disease in females and in males.

2016-2019 Behavioral and cell-based complementary screens to identify druggable targets modulating tau protein levels
#5R21NS096395

Grant funding from NIH-NIA

2015 - Pioneer SCA Translational Research Award

Grant funding from National Ataxia Foundation

2011 - Brain Disorders and Development Training Grant

NIH Ruth L. Kirschstein National Research Service Award

2009 - John J. Wasmuth Postdoctoral Fellowship

Hereditary Disease Foundation