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Ping Yi

Yi

Ping Yi, Ph.D., B.S.

Assistant Professor

Email

pyi@bcm.edu

Positions

Assistant Professor
Mol & Cell Biology-Mol.Regulation
91¹ú²úÊÓƵ
Houston, TX, US
Member
Dan L Duncan Comprehensive Cancer Center
91¹ú²úÊÓƵ
Houston, Texas, United States

Education

Advanced Training from Baylor College Of Medicine
01/2008 - Houston, TX, United States
Ph.D. from University Of Rochester
01/2002 - Rochester, NY, United States

Professional Interests

  • Cancer Biology, Nuclear receptor structure and function, Cell signaling

Professional Statement

My lab research has been focused on molecular regulation of oncogene activation in cancer, with a particular focus on post-translational modification and signal transduction pathways, and nuclear receptor structural studies. Current studies aim to explore the role of non-proteolytic ubiquitination in prostate and lung cancer development and progression. We employ diverse tools for the studies, including transgenic mouse models, PDX tumor models and a variety of molecular biology and cell biology tools. Another interest of the lab is to understand the structure and function of nuclear receptor-coregulator complexes. We are the first group to use cryo electron microscopy (Cryo-EM) to determine the quaternary structure of DNA-bound estrogen receptor alpha, Steroid Receptor Coactivator (SRC-3) and a secondary coactivator (p300) complex. Combining cryo-EM structural approach and biochemical analysis, we have elucidated a series of nuclear receptor complex structures.

Websites

Selected Publications

  • Yu, W., Singh, R., Wang, Z., O'Malley, B. W., Yi, P.. " " J. Biol. Chem.. 2021 ; 296 : 100739.
    Pubmed PMID: .
  • Yi, P., Wang, Z., Feng, Q., Pintilie, G. D., Foulds, C. E., Lanz, R. B., Ludtke, S. J., Schmid, M. F., Chiu, W., O’Malley, B. W.. " " Mol. Cell. 2015 ; 57 : 1047-1058.
    Pubmed PMID: .
  • Singh, R., Karri, D., Shen, H., Shao, J., Dasgupta, S., Huang, S., Edwards, D.P., Ittmann, M.M., O'Malley, B.W., Yi, P.. " " J. Clin. Invest.. 2018 ; 128 : 3129-3143.
    Pubmed PMID: .
  • Yi, P., Wang, Z., Feng, Q., Chou C. K., Pintilie, G. D., Shen, H., Foulds, C. E., Fan, G., Serysheva, I., Ludtke, S. J., Schmid, M. F., Hung, M. C., Chiu, W., O'Malley, B. W.. " " Mol. Cell. 2017 ; 67 : 733-743.
    Pubmed PMID: .

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