Ross A. Poché

Ross A. Poché, Ph.D.

Associate Professor

(713) 798-8380

Email

poche@bcm.edu

Positions

Associate Professor: Integrative Physiology
91��Ƶ
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
91��Ƶ
Houston, Texas, United States

Addresses

BCM-Ben Taub Research Center (Lab): Room: T440 (Lab) T424 (Office)
Houston, TX, 77030
United States

Education

BS from The University of New Orleans: 07/2001 - New Orleans, Louisiana, United States

PhD from 91��Ƶ: 07/2007 - Houston, Texas, United States

Postdoctoral Fellowship at 91��Ƶ: 07/2012 - Houston, Texas, United States

Professional Interests

Regenerative Medicine
Vision Sciences
Mouse Molecular Genetics
Developmental Biology

Professional Statement

One of my lab's long-term goals is to elucidate the transcriptional and epigenetic mechanisms regulating retinal progenitor cell proliferation and differentiation, leading to new therapeutic interventions to restore sight and treat cancers such as retinoblastoma. Toward that end, projects aimed at characterizing mouse mutants suffering from defects in retinogenesis are ongoing. One specific aspect of our research is to determine precisely how mitochondrial activity and other bioenergetic pathways interface with cell cycle progression during development. Additionally, we aim to identify new strategies to promote retinal regeneration in response to photoreceptor damage. Here, we are interested in determining whether the mouse retina retains latent regenerative potential akin to other vertebrates such as the zebrafish and whether we can genetically "re-awaken" that potential to restore sight.

Our second focus is on the generation and characterization of novel mouse models recapitulating human craniofacial and neurodevelopmental birth defects. Recently, we have uncovered a previously unknown transcription factor network that is responsible for development of the neural crest-derived craniofacial skeleton.

In the lab, we employ a multi-disciplinary approach utilizing genetic loss- and gain-of-function experiments, molecular biology and live retinal confocal microscopy.

Websites

BCM Lab Web Site

Selected Publications

Martin JF, Poché RA.. " " Development. 2019 Dec 2; 146 (23)
Pubmed PMID: .
Rueda EM, Hall BM, Hill MC, Swinton PG, Tong X, Martin JF, Poché RA. " " Cell Reports. 2019 May 7; 27 (6) : 1637-1649.
Pubmed PMID: .
Barrasso AP, Wang S, Tong X, Christiansen AE, Larina IV, Poché RA. " " Neural Dev.. 2018 Sep 15; 13
Pubmed PMID: .
Barrasso AP, Tong X, Poché RA.. " " Genesis. 2018 Dec 15;
Pubmed PMID: .
Poché RA, Zhang M, Rueda EM, Tong X, McElwee ML, Wong L, Hsu CW, Dejosez M, Burns AR, Fox DA, Martin JF, Zwaka TP, Dickinson ME.. " " Cell Rep.. 2016 Feb 23; 14 (7) : 1684-97.
Pubmed PMID: .
Poché R.A., Hsu, C.W., McElwee M.L., Burns, A.R. and Dickinson, M.E.. " " Dev. Biol.. 2015 Jul 1; 403 (1) : 30-42.
Pubmed PMID: .
Hsu CW, Poché RA, Saik JE, Ali S, Wang S, Yosef N, Calderon GA, Scott L Jr, Vadakkan TJ, Larina IV, West JL, Dickinson ME.. " " PLoS One. 2015 Jul 1; 10 (7)
Pubmed PMID: .
Lee C.S., Dagnino-Acosta A., Yarotskyy V., Hanna A., Lyfenko A., Knoblauch M., Georgiou D.K., Poché R.A., Swank M.W., Long C., Ismailov I.I., Lanner J., Tran T., Dong K., Rodney G.G., Dickinson M.E., Beeton C., Zhang P., Dirksen R.T. and Hamilton S.L.. " " Skelet Muscle. 2015 Jan 29;
Pubmed PMID: .
Keeley P.W., Luna, G., Skyles K.A., Madsen N., Raven M.A., Poché R.A., Swindell E.C., Jamrich M., Fisher S.K. and Reese B.E.. " " J Neurosci.. 2013 Nov 6;
Pubmed PMID: .
Culver J.C., Hoffman J.C., Poché R.A., Slater J.H., West J.L. and Dickinson M.E.. " " Adv Mater.. 2012 May 2;
Pubmed PMID: .
Poché R.A., Sharma R., Garcia M.D., Wada A.M., Nolte M.J, Udan R.S., Paik J.H., DePinho R.A., Bartlett J.D. and Dickinson M.E.. " " PLoS One. 2012 Jan 24;
Pubmed PMID: .
Whitney I.E., Raven M.A., Ciobanu D.C., Poché R.A., Ding Q., Elshatory Y., Gan L., Williams R.W., Reese B.E.. " " Proc Natl Acad Sci. 2011 Jun 7;
Pubmed PMID: .
Gould D.J., Vadakkan T.J., Poché R.A. and Dickinson M.E.. " " Microcirculation. 2011 Feb 18;
Pubmed PMID: .
Moon J.J., Saik J.E., Poché R.A., Leslie-Barbick J.E., Lee S.H., Smith A., Dickinson M.E., and West J.L.. " " Biomaterials. 2010 May 31;
Pubmed PMID: .
Poché R.A., Saik J.E., West J.L. and Dickinson M.E.. " " Cold Spring Harb Protoc.. 2010 Apr ;
Pubmed PMID: .
Poché R.A., Larina I.V., Scott M.L., Saik J.E., West J.L. and Dickinson M.E.. " " Dev Dyn.. 2009 Sep 23;
Pubmed PMID: .
Poché R.A. and Reese, B.E.. " " Development. 2009 Jul 1;
Pubmed PMID: .
Poché R.A., Furuta Y., Chaboissier M-C., Schedl A. and Behringer R.R.. " " J Comp Neurol.. 2008 Sep 20;
Pubmed PMID: .
Poché R.A., Raven M.A., Kwan K.M., Furuta Y., Behringer R.R. and Reese B.E.. " " Eur J Neurosci.. 2008 Apr 27;
Pubmed PMID: .
Poché R.A., Kwan K.M., Raven M.A., Furuta Y., Reese, B.E. and Behringer R.R.. " " J Neurosci.. 2007 Dec 19;
Pubmed PMID: .
Chern T, Achilleos A, Tong X, Hsu CW, Wong L, Poché RA. " " Dev. Biol.. 2020 Dec 1; 468 (1-2) : 1-13.
Pubmed PMID: .
Ambekar Y.S., Singh M., Scarcelli G., Rueda E.M., Hall B.M., Poché R.A.*, and Larin K.V.*. " " J Biomed Opt.. 2020 Sep 25;
Pubmed PMID: .
Burger C.A., Albrecht N.E., Jiang D., Liang J.H., Poché R.A., Samuel M.A.. " " Cell Rep.. 2021 Feb 2;
Pubmed PMID: .
Li-Villarreal N., Wong R.L.Y., Garcia M.D., Udan R.S., Poché R.A., Rasmussen T.F., Rhyner A.M., Wythe J.D., and Dickinson M.E.. " " Development. 2022 Apr 1;
Pubmed PMID: .
Chern T.*, Achilleos A.*, Tong X., Hill M.C., Saltzman A.B., Reineke L.C., Chaudhury A., Dasgupta S.K., Redhead Y, Watkins D., Neilson J.R., Thiagarajan P, Green J.B.A., Malovannaya A., Martin J.F., Rosenblatt D.S., and Poché R.A.. " " Nat Commun.. 2022 Jan 10;
Pubmed PMID: .
Chern T.*, Achilleos A.*, Tong X., Hill M.C., Saltzman A.B., Reineke L.C., Chaudhury A., Dasgupta S.K., Redhead Y, Watkins D., Neilson J.R., Thiagarajan P, Green J.B.A., Malovannaya A., Martin J.F., Rosenblatt D.S., and Poché R.A.. " " Nature Communications. 2022 Jan 10; 10
Pubmed PMID: .

Funding

“Ronin (Thap11) in Neural Crest Cell Development” #R01 DE028298: (07/15/2019 - 04/30/2024); NIH/NIDCR

“Hippo Pathway Regulation of Müller Glial Cell-mediated Retinal Regeneration”: (09/01/2019 - 06/30/2023); NIH/NEI

“Transcriptional Regulation of Retinal Mitochondrial Function and Cell Cycle”: (12/01/2014 - 11/30/2020); NIH/NEI

“Reawakening the Regenerative Potential of Mammalian Müller Glial Cells”: (07/01/2018 - 06/30/2021); Bright Focus Foundation

to edit your profile

91������Ƶ