91¹ú²úÊÓƵ

Email

wehrens@bcm.edu

Positions

Juanita P. Quigley Endowed Chair in Cardiology

91¹ú²úÊÓƵ
Houston, Texas, United States

Professor

Molec.Physiology/Wehrens
91¹ú²úÊÓƵ
Houston, TX, US

Director

Cardiovascular Research Institute
91¹ú²úÊÓƵ
Houston, Texas, United States

Professor

Medicine
Cardiology
91¹ú²úÊÓƵ

Addresses

BCM-Jewish Institute for Research (Office)

Room: BCMD-510D
Houston, TX, 77030
United States

BCM-Jewish Institute for Research (Lab)

Room: BCMD-510D
Houston, TX, 77030
United States

Education

M.D. from Maastricht University

01/2001 - Maastricht, Netherlands

Ph.D. from Maastricht University

01/2002 - Maastricht, Netherlands

Professional Interests

• Biochemistry and Biophysics
• Cardiovascular Sciences
• Human Disease
• Molecular mechanisms and mouse models of cardiac arrhythmias and heart failure
• Intracellular calcium homeostasis
• New drug development
• Cardiac gene therapy

Websites

Selected Publications

• Alsina KM, Hulsurkar M, Brandenburg S, Kownatski-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick SP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. " " Circulation. 2019 ; 140 (8) : 681-93.
  Pubmed PMID: .
• Ni L, Scott L Jr, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT.. " " Circ Res. 2019 ; 124 (2) : 256-62.
  Pubmed PMID: .
• Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. " In Vivo RyR2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. " Circ Res. 2019 Sep 28;
• Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Eissa TN, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N.. " " Circulation. 2018 Nov 18;
  Pubmed PMID: .
• Chiang DY*, Alsina KM*, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott, L, Heck AJR, Wehrens XHT. " " Circulation. 2018 Oct ;
  Pubmed PMID: .
• Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. " " Nature. 2012 Mar 1; 483 (7387) : 96-9.
  Pubmed PMID: .
• Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, Dealmeida A, Voigt N, Lawrence WS, Skapura DG, SkÃ¥rdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. " " Circ. Res.. 2012 May 25; 110 (11) : 1474-83.
  Pubmed PMID: .
• Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. " " Circ. Res.. 2012 Feb 3; 110 (3) : 465-70.
  Pubmed PMID: .
• Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. " " Circulation. 2012 Jun 5; 125 (22) : 2751-61.
  Pubmed PMID: .
• van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. " " Circulation. 2011 Mar 8; 123 (9) : 979-88.
  Pubmed PMID: .
• van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. " " Circulation. 2010 Dec 21; 122 (25) : 2669-79.
  Pubmed PMID: .
• Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. " " J. Clin. Invest.. 2009 Jul ; 119 (7) : 1940-51.
  Pubmed PMID: .
• Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. " " Cell. 2005 Oct 7; 123 (1) : 25-35.
  Pubmed PMID: .
• Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. " " Science. 2004 Apr 9; 304 (5668) : 292-6.
  Pubmed PMID: .
• Wehrens XH, Lehnart SE, Reiken SR, Marks AR. " " Circ. Res.. 2004 Apr 2; 94 (6) : e61-70.
  Pubmed PMID: .
• Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. " " Cell. 2003 Jun 27; 113 (7) : 829-40.
  Pubmed PMID: .

Show 12 more publications

Memberships

Heart Rhythm Society

Awards committee (05/2020)

American Society for Clinical Investigation

Member (02/2015)

Association of American Physicians

Member (04/2022)

Funding

Ryanodine receptor regulation in post-operative atrial fibrillation
#R01 HL089598

(07/15/2019 - 06/30/2023)

Grant funding from NIH/NHLBI

Mechanisms underlying atrial fibrillation associated with chronic kidney disease
#R01 HL147108

(04/15/2019 - 02/28/2023)

Grant funding from NIH-NHLBI

Junctophilin-2 cleavage in ischemic heart disease
#R01 HL153350

(04/01/2021 - 03/31/2025)

Grant funding from NIH/NHLBI

Role of nucleoside-diphosphate kinase signaling in atrial fibrillation
#R01 HL160992

(02/06/2023 - 01/31/2027)

Grant funding from NIH/NHLBI

Intellectual Property

Compounds for treatment of cardiac arrhythmias

Product Patent #WO2015085245A1 (Pending)

JP2016557534A US20160311760A1

Co Inventors: R.M. Strongin, J.J. Abramson, M. Sibrian-Vazquez

Languages

Dutch, German