91国产视频 the Lab
Our lab focuses on understanding the regenerative capacity of the vagina after injury toward developing novel therapies for scarless wound healing. Our group operates under the interdisciplinary team of physicians, scientists, and engineers in the Laboratory for Regenerative Tissue Repair at Texas Children鈥檚 Hospital. We are particularly interested in defining the roles of mechanical forces, extracellular matrix, and inflammation in the wound healing process using the vagina as an archetype model of regenerative responses to injury. We use our studies to translate bench discoveries into bedside applications in achieving anti-fibrotic therapies to improve outcomes for patients.
Pediatric gynecologist clinician-scientist, Dr. Julie Hakim, leads our group in exploring gynecologic innovation and device design. We are passionate about improving women and girls鈥 health via the study and evaluation of novel GYN related medical device designs. Among our pursuits of device design and innovation, we are pioneering vaginal stents specifically for adolescents to prevent complications from vaginal fibrosis after surgeries addressing reproductive anomalies. Our mission is to translate our research discoveries into clinical applications for developing vaginal anti-fibrotic therapies and ultimately improving outcomes for patients.
Studies
. Jennifer M McCracken, Swathi Balaji, Sundeep G Keswani, Julie C-E Hakim. Adv Wound Care. 2020; doi: 10.1089/wound.2020.1198. PMID: 32602816
. Megan Wancura, Jennifer M McCracken, Emily Steen, Elizabeth Cosgriff-Hernandez, Sundeep Keswani, Julie C-E Hakim. Curr Opin Obstet Gynecol. 2019 Oct;31(5):309-316. doi: 10.1097/GCO.0000000000000563. PMID: 31369479.
. Hakim J, Childress KJ, Hernandez AM, Bercaw-Pratt JL. J Adolesc Health. 2019 Aug;65(2):303-305. doi: 10.1016/j.jadohealth.2019.02.009. PMID: 31196784.
. Hakim J, Smith PA, Singh M, Han Z, Raghunathan R, Wyman O, Guffey D, Larin KV, Cohn W, Dietrich JE. Gynecol Obstet Invest. 2019;84(2):145-153. doi: 10.1159/000491696. PMID: 30269139.
. Kanner L, Hakim JCE, Davis Kankanamge C, Patel V, Yu V, Podany E, Gomez-Lobo V. J Pediatr Adolesc Gynecol. 2018 Dec;31(6):597-604. doi: 10.1016/j.jpag.2018.06.006. PMID: 29940314.
. Sack BS, Elizondo RA, Huang GO, Janzen N, Espinoza J, Sanz-Cortes M, Dietrich JE, Hakim J, Richardson ES, Oden M, Hanks J, Haridas B, Hury JF, Koh CJ. J Pediatr Surg. 2018 Mar;53(3):493-498. doi: 10.1016/j.jpedsurg.2017.01.06. PMID: 28196661
. Patel V, Hakim J, Gomez-Lobo V, Amies Oelschlager AM. J Pediatr Adolesc Gynecol. 2018 Feb;31(1):45-47. doi: 10.1016/j.jpag.2017.07.006. PMID: 28826904.
Vaginal Wound Healing
We are particularly interested in defining the roles of estrogen, mechanical forces, extracellular matrix (particularly hyaluronic acid) and inflammation in the wound healing process of vaginal tissue and committed to helping women鈥檚 vaginal heal better. We are investigating this in both in vitro and in vivo model systems as part of our basic science research arm.
Vaginal Device Design
We are developing vaginal stents suited for pediatric and adult patients to address anatomic-specific needs for these patients. We aim to reduce early discontinuation of stent use postoperatively and improve postsurgical outcomes with regards to restenosis for girls who have undergone neo-vaginal creation and for women who have undergone pelvic surgery or radiation due to gynecologic cancer treatment. It is our hope that this newly redesigned stent will also benefit post-radiation and post-hysterectomy patients by providing a more comfortable, ergonomic and efficient stent option than the currently available model
Vaginal Modeling
We are inspired by the tissue engineering community leading organs-on-chip efforts to create a 鈥渧agina on a chip鈥 model. We and collaborators are in devising such a biomimetic vaginal model to allow drugs or devices to be tested on a micro-sized replicate of the vaginal and reproductive environment to enhance discovery, efficacy and cost efficiency.