The Redondo Lab is interested in four research areas:
Type 1 Diabetes
Type 1 Diabetes Genetics
- To incorporate genetics in the prediction model for type 1 diabetes and in the selection of candidates for prevention and new onset trials.
- To use genetics along with other characteristics present at diagnosis to classify diabetes time timely and accurately in children of diverse racial/ethnic background.
Type 1 Diabetes Heterogeneity
- To understand the role of type 2 diabetes related factors (genetic, obesity, other) in the pathogenesis of type 1 diabetes.
- To define type 1 diabetes endotypes that can be leveraged for precision medicine diagnosis and treatment.
Type 1 Diabetes Prevention
Identify individuals at risk for type 1 diabetes and offer them clinical trials for prevention of progression.
Atypical Diabetes
- To study rare and atypical forms of diabetes and the potential role of the underlying mechanisms in common forms of diabetes
Race and Ethnicity in Diabetes
- To uncover the influence of race/ethnicity in the etiology, pathogenesis and clinical course of diabetes.
COVID-19 and Diabetes
- To study the relationships between COVID-19 and diabetes in children.
Publications
This list includes only mentees’ publications, presentations and active studies with Dr. Redondo as primary mentor in 2020.
| Name | Level | Title | Related First Authorship in 2020 |
|---|---|---|---|
| Dr. Mustafa Tosur | Faculty | The Effect of Ethnicity in the Rate of Beta Cell Functional Loss in the First Three Years After Type 1 Diabetes Diagnosis. | Tosur et al. J Clin Endocrinol Metab 2020 |
| Dr. Marcela Astudillo | Third-Year Fellow | Type 2 diabetes in children Identification of atypical diabetes using electronic medical records | Astudillo et al. American Diabetes Association 2020 presentations |
| Dr. Anna Cymbaluk | Second-Year Fellow | COVID-19 and diabetes | Project ongoing |
| Dr. Emily Crain | First-Year Fellow | Racial/ethnic differences in Insulin pump uptake | Project ongoing |
| Dr. Alex Siller | Resident | Challenges in the Diagnosis of Diabetes Type in Pediatrics | Siller et al. Pediatric Diabetes 2020 |
| Arielle Raugh | Graduate Student | Translational Biology & Molecular Medicine Graduate Program Clinical Projects Course | N/A |
| Beatriz Castillo | BCM Medical student | Type 2 diabetes heterogeneity by sex | Castillo et al. European Association of Pediatric Societies 2020 Virtual Congress |
| Jacob Nieto | Undergraduate | Type 1 diabetes heterogeneity by autoantibody type | Nieto et al. European Association of Pediatric Societies 2020 Virtual Congress |
| Sofia Fernandez-Weir | High school | Knowledge and perceptions about type 1 diabetes among high school students | Project ongoing |
| Teresa Nieto | High school | Typical characteristics of diabetes types | Nieto et al. European Association of Pediatric Societies 2020 Virtual Congress |
View a PubMed listing of .
Projects and Studies
- Type 1 Diabetes Genetic Risk Scores for the Diagnosis of Diabetes Type in Children of Diverse Racial and Ethnic, NIH NIDDK R01DK124395-01A1 (PI Redondo)
- Type 1 Diabetes Genetic Risk Score in TrialNet, NIH NIDDK R01 DK121843-01 (PI Redondo)
- TCH/BCM TrialNet Affiliate Center, NIH NIDDK (contract PI Redondo)
- Rare and Atypical Diabetes Network (RADIANT) Center, NIH NIDDK U54 DK118638-01 (PI Balasubramanyam, pediatric site PI Redondo)
- Enhancement of Biomarkers of Type 1 Diabetes, NIH NIDDK (PI Pietropaolo, Redondo Co-Investigator)
- Type 2 Diabetes in Children (Fellow Astudillo, senior Redondo)
- COVID-19 and diabetes (Fellow Cymbaluk, senior Redondo)
- TCH New Onset Diabetes Cohorts (PI Redondo)
- IgA and Microbiome in Pediatric Diabetes (PI Redondo)
The contact name, email and phone for the studies below is: Dr. Maria J. Redondo, redondo@bcm.edu, phone (832) 822-1019
- Type 1 Diabetes Genetic Risk Score In Trialnet, H-45218, (PI Redondo)
- Identification of Atypical Diabetes at TCH, H-45325, (PI Redondo)
- Chart Review: Pathogenic Heterogeneity of Autoimmune Type 1 Diabetes, H-27002 (PI Redondo)
- Type 1 Trialnet: Pathway to Prevention, H-27050, (PI Redondo)
- Trianet CTLA-4 IG (ABATACEPT) For Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At-Risk For Type 1 Diabetes Mellitus, H-36243, (PI Redondo)
- Testing the Accelerator Hypothesis: Obesity and Islet Autoimmunity, H-40265, (PI Redondo)
- Monogenic Diabetes in Children, H-41512, (PI Redondo)
- HETEROGENEITY OF TYPE 1 DIABETES, H-43976, (PI Redondo)
- COVID19 Infection In Youth With Diabetes, H-47411, (PI Redondo)
- Targeting the Tri-Moleular Complex with Insulin, AN-6973 (PI Zhang)
- Study of Dysglycemia To Identify A Pre-Clinical State of Type 1 Diabetes, H-36194 (PI Pietropaolo)
- Can Relational Agents Enhance Parent-Teen Communication to Improve T1D Outcomes?, H-37245 (PI Thompson)
- Suppression of Autoimmune Response of Type 1 Diabetes, H-38191 (PI Zhang)
- Recruitment Database for Human Subjects Research ub Type 1 Diabetes, H-38618 (PI Sisley)
- Biomarkers in Autoimmune Diabetes, H-41091 (PI PIetropaolo)
- Dissection of Heterogeneity In Children with Maturity-Onset Diabest of the Young (MODY), H-44887 (PI Tosur)
- Dissection of Heterogeneity of Pediatric Diabetes Using Islet Autoimmunity and Beta-Cell Function: A Prospective Pilot Study, H-45745 (PI Tosur)
- Rare and Atypical Diabetes Network (Radiant), H-46235 (PI Balasubramanyam)
- A Clinical and Biological Analysis of Patients With Endocrine Disorders in Children Less Than 21 Years of Age, H-47418 (PI Sisley)
Maria Redondo Lab
Texas Children’s Hospital, Diabetes & Endocrinology Section
6701 Fannin Street, MWT 10th floor, Houston, TX 70030
Email: redondo@bcm.edu, Phone 832-822-1019